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An earlier short-term double-blind study in patients with acute exacerbations of schizophrenia showed that amisulpride was as effective as risperidone in treating positive symptoms and showed a trend toward greater improvement in negative symptoms; moreover, amisulpride was associated with significantly less weight gain than risperidone ().

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However, because of the adverse adverse-effect profile of clozapine and the significant metabolic risks associated with olanzapine, PORT advised that neither drug should be considered as a first-line treatment for first-episode schizophrenia.

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Clozapine is an atypical antipsychotic medication recommended for Treatment resistant schizophrenia where the illness has not responded satisfactorily to treatment despite sequential use of adequate doses of, at least, two different antipsychotics, prescribed for adequate duration.

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In the 1970s, tens of thousands of patients were put on antipsychotic drugs and released from institutions into the community, a concept called deinstitutionalization.

The Medline database was searched for all studies of amisulpride in schizophrenia which reported functional and quality of life outcomes up until 30 September 2009.

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However, the significant association observed in cannabidiol-treated patients between improvement of clinical symptoms and serum anandamide levels suggests that the ability of cannabidiol to inhibit the FAAH activity and enhance intrinsic anandamide signaling might be a functionally relevant component of its antipsychotic properties.

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This may be a result of previous conventional antipsychotic treatment, in that nicotine may ameliorate some of the adverse effects of these drugs.

Polymorphisms of the 5-HT 2C receptor and leptin genes are associated with antipsychotic drug-induced weight gain in caucasian subjects with a first-episode psychosis.

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The impact of cannabis use on cognitive functioning in patients with schizophrenia: a meta-analysis of existing findings and new data in a first-episode sample.

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Hyoscyamus Niger this homeopathic remedy is useful for those cases of Schizophrenia where the main symptom is delusion of persecution and the patient feels that others are making some plot against him.

In total, the study examined 39 patients, dosing 20 with CBD and 19 with amisulpride.

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Amisulpride was associated with fewer extrapyramidal adverse effects and fewer drop-outs because of adverse events than conventional drugs.

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The investigators plan to test carefully the possible benefits and problems when the antipsychotic amisulpride or a dummy tablet ('placebo') is added to clozapine for 12 weeks in people whose schizophrenia illness has not been helped much by any antipsychotic medication on its own, and who are now taking clozapine, but again with not much improvement.

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