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What is FMF? Familial Mediterranean fever (FMF) is a hereditary inflammatory disorder. FMF is an autoinflammatory disease caused by mutations in Mediterranean fever gene, which encodes a 781–amino acid protein called pyrin.
What chromosome is affected by familial Mediterranean fever? Familial Mediterranean fever is almost always inherited in an autosomal recessive pattern, which means both copies of the MEFV gene in each cell have mutations.
What causes recurring fever? Approach to recurrent fevers in childhood. Although repeated febrile episodes are common in young children and often caused by acute viral infections, family members frequently worry about other potential causes such as chronic infections, immune system defects, malignancy, and inflammatory conditions.
Is familial Mediterranean fever dominant or recessive? Familial Mediterranean fever (FMF) is generally inherited in an autosomal recessive manner. For some affected individuals, the family history of FMF is consistent with an autosomal dominant manner of inheritance.
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