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It is exemplified by slow initial movements, difficulty getting up from a sitting position, involuntarily slowing or stopping while walking, and little or no change in facial expressions that may seem inappropriate to people who do not know that the person has Parkinson's disease.

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While this finding could reflect a unique property of pramipexole, it might also be explained by the conditions of the study and the nature of the population enrolled in the clinical trials.

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The abnormal ratio of four-repeat to three-repeat tau was mentioned above, and much current research is aimed at discovering what it is about the H1 haplotype of tau that causes damage.

The treatment lasts on an average of 6 months.

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Pramipexole total oral clearance was approximately 30% lower in subjects older than 65 years compared with younger subjects, because of a decline in pramipexole renal clearance due to an age-related reduction in renal function.

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The average life expectancy of a person with PD is generally the same as for people who do not have the disease.

This medication may be harmful to an unborn baby.

The limitation of levodopa or levodopa-carbidopa therapy is that after approximately two years of treatment, the drugs cease to work reliably.

Another criterion for substance dependence includes “a persistent desire or unsuccessful efforts to cut down or control substance use.

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