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Changes from baseline in global indicators of mood, physical well-being, and coping effort were similar in the two treatment groups during the treatment period.

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The BIG 1-98 Collaborative Group found that disease-free survival was not significantly better between 2 sequential treatment groups with letrozole and letrozole monotherapy and that overall survival was not statistically different between monotherapy with letrozole and monotherapy with tamoxifen (when combined with previous trial data comparing efficacy in 4922 postmenopausal patients with endocrine-responsive breast cancer for letrozole).

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Switching to letrozole or exemestane improves hot flushes, mood and quality of life in tamoxifen intolerant women.

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Exemestane is freely soluble in tetrahydrofuran and dimethylformamide; soluble in acetone, acetonitrile, methanol, and ethyl acetate; sparingly soluble in ethanol; very slightly soluble in nhexane and insoluble in water.

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The results demonstrated that, compared to the group that received preoperative AC alone, the group that received preoperative AC followed by preoperative docetaxel achieved significantly higher rates of cCR (cCR: 40.

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However, the patients enrolled in the studies had lower-risk characteristics than had been anticipated in the design assumptions, and the rate of disease-free survival was better than expected.

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