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Effects of fatigue on activities of daily living and lifestyle.

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IV route results in increased doses of 13% to 26% based on past Canadian studies, which results in significantly increased drug cost (Moist et al.

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Nearly 40% of HIV-infected veterans on highly active antiretroviral therapy (HAART) are coinfected with HCV() compared to the approximately 25% of HIV-infected patients who are coinfected with HCV in the United States, nationally.

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Reverse transcriptase PCR (RT-PCR) is more sensitive than bDNA testing.

The dose conversion depicted in Table 1 does not accurately estimate the once monthly dose of darbepoetin alfa.

Therefore, consuming enough vitamins and minerals, such as iron, will help you to fight off infections and to feel as well as possible during treatment.

Brand name: PROCRIT, EPOGEN, by Amgen.

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After three months of treatment, the median had increased by exactly 50 percent, to 35.

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Corrects erythropoietic abnormalities caused by a deficiency of iron.

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The finding that the levels were highest in our patients with late responses or none could merely be a phenomenon of chance, but preliminary data on patients with other chronic diseases seem to corroborate our findings.

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Peginterferon-alpha2a and ribavirin combination therapy in chronic hepatitis C: a randomized study of treatment duration and ribavirin dose.

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Increases in blood pressure have been reported in clinical trials, often during the first 90 days of therapy.

Although the approval speed for new biosimilars are getting lower in the two last years (only one new approval since June 2009), more to come with the patent expiries of monoclonal antibodies.

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Safety concerns associated with Aranesp (darbepoetin alfa) Amgen, Inc.

Bone marrow changes following treatment of renal anemia with erythropoietin.

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AHRQ CER provided very similar results.

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The number of BFU-E in the bone marrow was very low before erythropoietin treatment (median, 0; range, 0 to 7).

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This last comparison is proof of biosimilarity at the quality level.

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Hb increased to the targeted range, it then remained in the target range through week 28.

Kralovics R, Passamonti F, Buser AS, Teo SS, Tiedt R, Passweg JR, Tichelli A, Cazzola M, Skoda RC (2005).

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Specific risk factors for thromboembolism have not been defined in these trials; therefore, clinicians should use caution and clinical judgment when considering use of these agents.

Food and Drug Administration: FDA announces new safety plan for agents used to treat chemotherapy-related anemia.

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To date, the EMA has approved 14 biosimilars within the product classes of human growth hormone, granulocyte stimulating factor and erythropoietin, for use in the EU, see Table below.

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At week 30, patients treated with the Infliximab biosimilar displayed antibody incidences of 27.

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In patients who cannot tolerate ACE inhibitors, an angiotensin receptor blocker (ARB) may reasonably be prescribed.

Optimization of epoetin therapy with intravenous iron therapy in hemodialysis patients.

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Low blood counts including a low platelet count can occasionally occur after receiving a lot of chemotherapy or radiation therapy.

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Another type could prove to be the result of suppression or impairment of the bone marrow response to stimulation by erythropoietin; substitution treatment could not be expected to benefit patients with this type of anemia.

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Managing Anemia and Metabolic Bone Disease in Dialysis Patients.

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In a randomized, double-blind, placebo-controlled study of 4038 patients, there was an increased risk of stroke when darbepoetin alfa was administered to patients with anemia, type 2 diabetes, and CRF who were not on dialysis.

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Interferons are cell signaling chemicals that have been used in the treatment of leukemia.

Three trials compared different weight-based doses of epoetin, and three compared different weight-based doses of darbepoetin; five compared different fixed doses of epoetin; one trial each compared weight-based versus fixed doses for epoetin and darbepoetin, respectively; two compared more versus less frequent dosing of epoetin; two compared front-loaded versus reduced or constant dosing of darbepoetin; and one compared titrated versus constant-dose regimens of epoetin.

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