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While most of the patients will be on dialysis, epoetin beta can be used if patients with chronic renal insufficiency develop a symptomatic anaemia before starting dialysis.
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Expression of EPOR, βCR, and growth hormone receptor at the mRNA and protein levels was demonstrated with reverse transcriptase polymerase chain reaction and Western blot analysis.
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We enrolled 605 patients, but 2 were excluded from the analysis because they were from a center that was closed owing to failure to adhere to Good Clinical Practice guidelines ( Figure 1 Enrollment, Randomization, and Study Completion.
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In these cases, epoetin alfa is used to replace the missing hormone or to increase red blood cell counts.
Hellstrom-Lindberg E, Ahlgren T, Beguin Y et al (1998) Treatment of anemia in myelodysplastic syndromes with granulocyte colony-stimulating factor plus erythropoietin: results from a randomized phase II study and long-term follow-up of 71 patients.
Patients were censored for survival at 4 weeks after the last entry in the administration record.
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Safety of erythropoiesis-stimulating agents in patients with end-stage kidney disease: data are safer than extrapolations.
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The present invention also contemplates compositions and formulations comprising agents, compounds, or drugs selected from the group consisting of germacrene, guaiazulene, guaiol, gurjunene, hexahydrohumulene, himachalene, hinesol, humulene, junipene, longifolene, lubiminol, khusimone, khusinol, khusimol, nootkatone, santalene, santalol, santanol, santonene, selinene, solavetivone, spatulenol, sterpurine, sulcatine, thujopsene, valerenol, vetispirene, vetivazulene, vetivene, vetiverol, vetivone, viridiflorine, and viridiflorol as well as their derivatives and analogs.
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The method of claim 17, wherein the therapeutic agent or carrier is directly conjugated to a targeting molecule by: (a) non-specific or specific protein-protein interaction; (b) covalent bonding; (c) non-covalent bonding; or (d) coordinating chemical bonding; which conjugation is optionally effected via a spacer or linker that bridges between the therapeutic agent or carrier and the targeting molecule, or (e) a recombinant fusion or hybrid polypeptide.
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