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The median duration of the neutropenic and thrombocytopenic episodes varied from 2 to 3 weeks, and from 2 to 4 weeks, respectively.

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Impact of imatinib rechallenge on health-related quality of life in patients with TKI-refractory gastrointestinal stromal tumours: Sub-analysis of the placebo-controlled, randomised phase III trial (RIGHT).

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Kearon C, Akl EA, Comerota AJ, et al.

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Jones et al analyzed the relative weight gain among other adverse effects of paliperidone versus all other SGAs except ziprasidone, asenapine, and iloperidone.

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The frequencies of these reported adverse reactions were similar in Study 2, comparing 12 vs 36 months of GLEEVEC treatment (12 mo; 36 mo), except for decreased hemoglobin (72%; 80%), periorbital edema (59%; 74%), muscle spasms (31%; 49%), decreased white blood cell count (35%; 47%), pain (26%; 46%), peripheral edema (33%; 41%), rash (29%; 39%), arthralgia (9%; 17%), and myalgia (9%; 15%), which were higher among patients receiving 36 months of adjuvant treatment with GLEEVEC.

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Antiangiogenic effects include inhibition of vascular endothelial growth factor (VEGF), an angiogenic cytokine secreted by bone marrow stromal cells and myeloma cells.

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Knock-down of CIAPIN1 sensitizes K562 chronic myeloid leukemia cells to Imatinib by regulation of cell cycle and apoptosis-associated members via NF-κB and ERK5 signaling pathway.

Dose titration of Imatinib, Nilotinib and Dasatinib and analysis of effects on NK cell reactivity.

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Before participating in the study, none of the patients had benefited from standard treatments used to remove arterial blockages in the brain.

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Imatinib mesylate was the first tyrosine kinase inhibitor to be successfully used in clinical practice.

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The study highlights an issue many new moms have to deal with, said one pediatrician who reviewed the new study.

Thus, it would be tempting to elucidate the exact mechanism by which imatinib affects CCR2 expression and which CCR2 carriers are particularly targeted.

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Mallone K, Hinman A. Vaccine Mandates: The Public Health Imperative and Individual Rights.

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Corticosteroids can reverse severe imatinib-induced hepatotoxicity.

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The first trial found no significant difference in disability rates between the two groups of patients.

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