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My father was prescribed with Zometa to treat multiple myeloma. And I think the medication is the reason why the last years of his life were comparatively enjoyable and happy. The thing is that he was diagnosed with lung cancer about ten years ago. All this time he was struggling hard for his life and health. But the disease turned out to be stronger than he was. Actually lung cancer diagnosis was a shock for him as he was not a heavy smoker, he smoked when he was younger but that was a short period of time. And his work was not connected with any chemicals or other harmful substances to breathe in. sad but true, he developed lung cancer. During long years of treatment he has changed many medications, some of them were more effective, others less. But in general we were sure the treatment was bringing positive results. There were periods of time when my father was active as before he was diagnosed with cancer, and he felt himself healthy, but then the disease would come back and we had to look for another treatment option. After one of such remission periods my father's doctor told us that unfortunately in spite of all the efforts the cancer spread to bones. That was a tough blow, we all were destroyed. My father was put on Zometa to slow down disease spreading in the bones. It was very painful at times, but Zometa helped a lot. My father lived 3 more years and due to this medication he was able to enjoy the rest of his life and spend many happy hours with his family. He's no longer with us, but we are grateful to Zometa for helping him forget about pain and sufferings at least for some time.

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Avastin has been combined with each of these in some second line trials, and these regimens appear to be generally safe (with a very small group of patients having serious or even fatal bleeding complications, a recurring theme with Avastin, though it does show an overall survival benefit in first line treatment despite some increased risks).

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The following factors have been associated with an increased risk: Pre-existing renal dysfunction, dehydration, multiple cycles of zoledronic acid (the active ingredient contained in Aclasta) or other bisphosphonates, concomitant use of nephrotoxic medicines and use of a shorter infusion time than what is recommended.

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The effect of 3 versus 6 years of Zoledronic acid treatment of osteoporosis: A randomized extension to the HORIZON-Pivotal Fracture Trial (PFT).

Determination of rat vertebral bone compressive fatigue properties in untreated intact rats and zoledronic-acid-treated, ovariectomized rats.

Zoledronic acid is not an anticancer drug, and it will not stop or slow the spread of cancer.

This means with a single treatment, a patient can receive a full year's protection against the effects of osteoporosis.

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