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Women with metastatic disease that is HER2-positive can also benefit from trastuzumab, sometimes as monotherapy, with very good results (NCI, 2013c).
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If you have early-stage breast cancer and had not gone through menopause when you were first diagnosed, your doctor might recommend taking tamoxifen first, and then taking an AI later if you go through menopause during treatment.
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To evaluate the efficacy of aromatase inhibitor (letrozole) in the treatment of endometriosis-related pain.
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Administration of letrozole resulted in rates of conception, clinical pregnancy, and live birth that were statistically noninferior to the rates with clomiphene, according to our prespecified noninferiority margin of 25%.
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For estrogen receptor (ER)-positive early-stage breast cancer, molecular tests are available to assist in answering two important questions: who benefits from adjuvant chemotherapy, and who remains at risk for late recurrence despite 5-years of adjuvant endocrine therapy and therefore may require extended adjuvant endocrine therapy?
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Phase Ib dose escalation only: Any number of prior lines of endocrine therapy is allowed with the exception of cytotoxic therapy which is limited to one prior line administered in the advanced (metastatic or locally advanced) setting.
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In the diagram, the adrenal gland (1) releases androstenedione (3) while the ovaries (2) secrete testosterone (4).
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