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In September 2010, a study published in the British Medical Journal raised questions about a possible link between long-term use of bisphosphonates and cancer of the esophagus.

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You should ensure that you speak to your pharmacist or doctor to obtain the most up to date information on the medicine.

As noted in the official FDA-approved Fosamax label, “Fosamax, like other bisphosphonates, may cause local irritation of the upper gastrointestinal mucosa.

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The Orthopaedic Implications of Diphosphonate Therapy.

Should people with severe osteoporosis take a different view and path than those dealing with osteopenia or borderline diagnoses?

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Montella L, Merola C, Merola G, Petillo L, Palmieri G (2009) Zoledronic acid in treatment of bone lesions by Langerhans cell histiocytosis.

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Reid IR, Brown JP, Burckhardt P, Horowitz Z, Richardson P, Trechsel U, Widmer A, Devogelaer JP, Kaufman JM, Jaeger P, Body JJ, Brandi ML, Broell J, Di Micco R, Genazzani AR, Felsenberg D, Happ J, Hooper MJ, Ittner J, Leb G, Mallmin H, Murray T, Ortolani S, Rubinacci A, Saaf M, Samsioe G, Verbruggen L, Meunier PJ (2002).

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Therapy Insight: the risks and benefits of bisphosphonates for the treatment of tumor-induced bone disease.

The Endocrine Society guidelines suggest re-treatment is seldom required within 5 years (Singer, 2014).

Keating and Scott (2007) stated that the third-generation nitrogen-containing bisphosphonate zoledronic acid is approved in the European Union for the treatment of Paget's disease of bone.

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