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Two subjects (one on placebo with unstable angina requiring hospitalization and one on ranolazine with urgent revascularization and unstable angina requiring hospitalization) had AEs that were adjudicated by the clinical events committee as major cardiovascular events.
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In the second series, the agents were added to the perfusate during ACh-mediated persistent AF (on the 5-6 th minutes after the start of the arrhythmia).
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Evaluation of Ranolazine in Patients with Type 2 Diabetes Mellitus and Chronic Stable Angina.
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At equivalent, noncompeting concentrations, in isolated working rat hearts, the oxidation of unsaturated fatty acids such as oleate () or arachidonic acid () occurs at similar rates to that of the saturated fatty acid palmitate.
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