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The relevance of these animal findings to humans has not been established.

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Only slight to moderate increases in Pantoprazole AUC (43%) and C max (26%) were found in elderly volunteers (64 to 76 years of age) after repeated oral administration, compared with younger subjects.

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2 More than 80 of uncomplicated UTIs are caused by uropathogenic Escherichia coli UPEC, 5 to 15 by Staphylococcus saprophyticus, and the remaining few cases by Enterococcus and Klebsiella species and Proteus mirabilis.

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