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Older children and adults with sickle cell disease may experience a few complications, or have a pattern of ongoing problems that shorten their lives.

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When people with sickle cell disease get acute chest syndrome, they may have severe chest and abdominal pain, fever, cough, and trouble breathing.

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On September 1, 2003, the trial was closed and a letter sent to investigators recommending that they consider changing the treatment of participating patients from anagrelide to hydroxyurea.

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Sickle cell disease, a genetic disorder that affects people of African, Middle Eastern, Mediterranean and Hispanic descent, is marked by abnormally C-shaped or "sickled" red blood cells -- the cells that store and distribute oxygen throughout the body.

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Weiss and his colleagues published their findings online recently in the American Journal of Clinical Nutrition.

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Patients with seizures, severe confusion, coma, or signs of brainstem herniation may need hypertonic (3%) saline to correct sodium levels, but only enough to arrest the progression of symptoms.

Older children and adult patients with sickle cell are subject to other medical problems, including impaired physical development and gum disease.

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Hip dysplasia and unilateral renal dilatation are not rare and there is no argument to correlate them with HU exposure.

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In addition, the disease is associated with significant health challenges including recurrent debilitating pain, chronic anaemia and stroke.

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Born with the most severe form of sickle cell disease, sickle cell anemia, Tiffany has lived with the symptoms and complications of this disease her entire life.

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In practice, despite previously reported teratogenicity in animals with high doses, we did not find any major malformation among the 31 human pregnancies exposed to therapeutic doses of HU.

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