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Finally a trifluoromethyl group at position 3 was found to give the best results, with approximately 36-fold improvement over imatinib.

Furthermore, if patients were treated with a drug that blocked multiple ATP-binding pockets rather than only one specific pocket, these patients would certainly experience devastating side effects.

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In patients with hypereosinophilic syndrome with occult infiltration of HES cells within the myocardium, cardiogenic shock and left ventricular dysfunction have been associated with HES cell degranulation upon initiation of GLEEVEC.

Generally, it does not cause any problems, nor does it require stopping the treatment.

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Research has led to the understanding of the molecular mechanisms underlying CML and allowed the development of effective targeted therapies.

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Clinical trials were soon expanded to include other patients with CML, and results were similarly stunning.

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If the tumor is large or lies in a difficult location, your doctor may prescribe a short course of targeted treatment before the surgery.

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Gleevec belongs to a group of drugs called protein-kinase inhibitors.

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The majority of the approximately 1700 adult patients who received Gleevec in clinical studies experienced adverse events at some time, but most were mild to moderate in severity.

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Drug was discontinued for adverse reactions in 57 patients (17%) and 11 patients (3%) of the Gleevec and placebo treated patients respectively.

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Later, during the course of prosecution, appeals, and the litigation that ensued in India, Novartis undertook studies to compare the properties of the beta crystalline form of imatinib mesylate (described in its new patent application), with the freebase form of imatinib (described in the older patent), and submitted them in affidavits.

Patients newly prescribed imatinib receive blood tests (more frequent early in therapy) to identify any liver function or blood count abnormalities.

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CML concluded that in terms of hematologic and cytogenetic responses, tolerability, and the likelihood of progression to accelerated-phase or blast-crisis CML, imatinib is superior to interferon alfa plus low-dose cytarabine as first-line therapy in newly diagnosed, chronic-phase CML.

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Sunitinib helps some patients, usually by slowing the growth of the tumor.

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