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Predicted interaction of compound 6A60 with DEN2V NS2B-NS3.

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Those with live lice present at any time up to the final evaluation were considered treatment failures.

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Boxes represent protease residues predicted to interact with inhibitor pharmacophores based on the described computational docking studies.

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Since the viral NS2B-NS3 protease (DEN2V NS2B-NS3pro) is required for viral replication, it provides a strategic target for the development of antiviral drugs.

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Three days later the mites that have plagued us for almost a year are gone.

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Healing of summer sores involving extensive tissue changes may require other therapy in conjunction with ivermectin.

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SAR and docking analysis using all tested anthracene-based analogs suggested that the inhibitors (with the exception of ARDP0006) formed contacts with the catalytic residue His51 of the protease.

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